oprelvekin   Click here for help

GtoPdb Ligand ID: 6971

Synonyms: Neumega®
Approved drug Immunopharmacology Ligand
oprelvekin is an approved drug (FDA (1997))
Compound class: Peptide
Comment: This is a non-glycosylated, recombinant form of human IL-11 produced in E.coli. Oprelvekin is one amino acid shorter than the endogenous peptide, lacking the amino-terminal proline residue.
No information available.
Summary of Clinical Use Click here for help
This drug is used to increase platelet counts in patients receiving chemotherapy, to circumvent drug-induced thrombocytopenia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Oprelvekin binds to the interleukin 11 receptor inducing thrombopoietic events including proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induction of megakaryocyte maturation, which culminate in increased platelet production.
External links Click here for help
For extended ADME data see the following:

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