capecitabine   Click here for help

GtoPdb Ligand ID: 6799

Synonyms: Ro-09-1978-000 | Ro-091978000 | Xeloda®
Approved drug
capecitabine is an approved drug (FDA (1998), EMA (2001))
Compound class: Synthetic organic
Comment: Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil (active agent). It is a thymidylate synthase inhibitor.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 122.91
Molecular weight 359.15
XLogP 2.04
No. Lipinski's rules broken 0
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Canonical SMILES CCCCCOC(=O)Nc1nc(=O)n(cc1F)C1OC(C(C1O)O)C
Isomeric SMILES CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C
InChI InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1998), EMA (2001))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
Is prodrug? Yes
Active form 5-fluorouracil
IUPAC Name Click here for help
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
International Nonproprietary Names Click here for help
INN number INN
7317 capecitabine
Synonyms Click here for help
Ro-09-1978-000 | Ro-091978000 | Xeloda®
Database Links Click here for help
CAS Registry No. 154361-50-9
ChEMBL Ligand CHEMBL1773
DrugBank Ligand DB01101
DrugCentral Ligand 480
GtoPdb PubChem SID 178103405
PubChem CID 60953
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Wikipedia Capecitabine

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Capecitabine (links to external site)
Cat. No. 4799