galectin-1   Click here for help

GtoPdb Ligand ID: 6603

Synonyms: GBP
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
Species: Human
Natural/Endogenous Targets
Target
RTP Type C
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Putative endogenous ligands at RTP Type C galectin-1 (LGALS1, P09382) 4
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
GB1908 Small molecule or natural product Hs Inhibitor Inhibition 7.2 pKd - 5
⤷ pKd 7.2 (Kd 5.7x10-8 M) [5]
Description: Binding affinity for galectin-1
GB1908 Small molecule or natural product Hs Inhibitor Inhibition 6.1 pIC50 - 5
⤷ pIC50 6.1 (IC50 8.5x10-7 M) [5]
Description: Measuring inhibition of galectin-1-mediated apoptosis in Jurkat cells