zofenopril   Click here for help

GtoPdb Ligand ID: 6462

Synonyms: SO-26991 | SQ-26900
Approved drug
zofenopril is an approved drug
Compound class: Synthetic organic
Comment: Metabolised to the active from zofenoprilat. The United States Adopted Name (USAN) for this compound is zofenopril calcium (PubChem CID 3033690).

zofenopril is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 125.28
Molecular weight 429.11
XLogP 4.11
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C(N1CC(CC1C(=O)O)Sc1ccccc1)C(CSC(=O)c1ccccc1)C
Isomeric SMILES O=C(N1C[C@H](C[C@H]1C(=O)O)Sc1ccccc1)[C@@H](CSC(=O)c1ccccc1)C
InChI InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1
InChI Key IAIDUHCBNLFXEF-MNEFBYGVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes.
Is prodrug? Yes
Active form zofenoprilat
IUPAC Name Click here for help
(2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
5535 zofenopril
Synonyms Click here for help
SO-26991 | SQ-26900
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9619010
Reactome Reaction Reactome logo R-HSA-9619024
Other databases
CAS Registry No. 81872-10-8 (source: PubChem)
ChEMBL Ligand CHEMBL331378
DrugCentral Ligand 2866, 2866
GtoPdb PubChem SID 178103076
PubChem CID 92400
Search Google for chemical match using the InChIKey IAIDUHCBNLFXEF-MNEFBYGVSA-N
Search Google for chemicals with the same backbone IAIDUHCBNLFXEF
Search PubMed clinical trials zofenopril
Search PubMed titles zofenopril
Search PubMed titles/abstracts zofenopril
UniChem Compound Search for chemical match using the InChIKey IAIDUHCBNLFXEF-MNEFBYGVSA-N
UniChem Connectivity Search for chemical match using the InChIKey IAIDUHCBNLFXEF-MNEFBYGVSA-N
Wikipedia Zofenopril

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MedChemExpress
Zofenopril (links to external site)
Cat. No. HY-108321