Synonyms: AY-22989 | Fyarro® (sirolimus albumin-bound particles) | Rapamune® | rapamycin | WY-090217
sirolimus is an approved drug (FDA (1999), EMA (2001))
Compound class:
Synthetic organic
Comment: Sirolimus is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has potent immunosuppressive and antiproliferative properties. Sirolimus is classified as a Type IV allosteric kinase inhibitor [10].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: sirolimus |
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1999), EMA (2001)) |
International Nonproprietary Names | |
INN number | INN |
7104 | sirolimus |
Synonyms |
AY-22989 | Fyarro® (sirolimus albumin-bound particles) | Rapamune® | rapamycin | WY-090217 |
Database Links | |
Specialist databases | |
Reactome Drug | R-ALL-9678687 |
Reactome Reaction | R-HSA-9679044 |
Other databases | |
CAS Registry No. | 53123-88-9 |
ChEBI | CHEBI:9168 |
ChEMBL Ligand | CHEMBL413 |
DrugBank Ligand | DB00877 |
DrugCentral Ligand | 2446 |
GtoPdb PubChem SID | 178102653 |
Immunopaedia Search | sirolimus |
LIPID MAPS | LMPK06000003 |
PubChem CID | 5284616 |
RCSB PDB Ligand | RAP |
Search Google for chemical match using the InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
Search Google for chemicals with the same backbone | QFJCIRLUMZQUOT |
Search PubMed clinical trials | sirolimus |
Search PubMed titles | sirolimus |
Search PubMed titles/abstracts | sirolimus |
SynPHARM | 80549 (in complex with FK506 binding protein 1A) |
UniChem Compound Search for chemical match using the InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
Wikipedia | Sirolimus |
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Rapamycin (links to external site)
Cat. No. 1292 |