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QRFP26 (26RFa)   Click here for help

GtoPdb Ligand ID: 5895

Synonyms: 26RFa | P518
Compound class: Endogenous peptide in human, mouse or rat
Comment: 26RFa is an orexigenic neuropeptide [3-5]. It is an endogenous agonist of the pyroglutamylated RFamide peptide receptor QRFPR (formerly known as GPR103).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Régo JC, Vandesande F, Llorens-Cortes C, Costentin J et al.. (2003)
Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.
Proc Natl Acad Sci USA, 100 (25): 15247-52. [PMID:14657341]
2. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J et al.. (2003)
Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
J Biol Chem, 278 (30): 27652-7. [PMID:12714592]
3. Leprince J, Bagnol D, Bureau R, Fukusumi S, Granata R, Hinuma S, Larhammar D, Primeaux S, Sopkova-de Oliveiras Santos J, Tsutsui K et al.. (2017)
The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24.
Br J Pharmacol, 174 (20): 3573-3607. [PMID:28613414]
4. Prévost G, Jeandel L, Arabo A, Coëffier M, El Ouahli M, Picot M, Alexandre D, Gobet F, Leprince J, Berrahmoune H et al.. (2015)
Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.
Diabetes, 64 (8): 2805-16. [PMID:25858563]
5. Ukena K, Vaudry H, Leprince J, Tsutsui K. (2011)
Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates.
Cell Tissue Res, 343 (3): 475-81. [PMID:21274569]