Synonyms: 6-n-octyl aminouracil
Compound class:
Synthetic organic
Comment: 6-n-octylaminouracil is a lipid-mimetic structure that acts as a synthetic GPR84 agonist [3].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
GPR84 | Medium chain free fatty acids with carbon chain lengths of 9-14 activate GPR84 [3-4]. A surrogate ligand for GPR84, 6-n-octylaminouracil has also been proposed [3]. See review [1] for discussion of classification. Mutational analysis and molecular modelling of GPR84 has been reported [2]. |