motesanib   Click here for help

GtoPdb Ligand ID: 5660

Synonyms: AMG 706 | AMG-706
PDB Ligand
Compound class: Synthetic organic
Comment: Motesanib is a pan-VEGFR inhibitor that was investigated for anti-tumourigenic efficacy.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 78.94
Molecular weight 373.19
XLogP 2.99
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES O=C(c1cccnc1NCc1ccncc1)Nc1ccc2c(c1)NCC2(C)C
Isomeric SMILES O=C(c1cccnc1NCc1ccncc1)Nc1ccc2c(c1)NCC2(C)C
InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8828 motesanib
Synonyms Click here for help
AMG 706 | AMG-706
Database Links Click here for help
CAS Registry No. 453562-69-1
ChEMBL Ligand CHEMBL572881
GtoPdb PubChem SID 178102288
PubChem CID 11667893
RCSB PDB Ligand 706
Search Google for chemical match using the InChIKey RAHBGWKEPAQNFF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RAHBGWKEPAQNFF
Search PubMed clinical trials motesanib
Search PubMed titles motesanib
Search PubMed titles/abstracts motesanib
UniChem Compound Search for chemical match using the InChIKey RAHBGWKEPAQNFF-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey RAHBGWKEPAQNFF-UHFFFAOYSA-N
Wikipedia Motesanib