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dexlansoprazole   Click here for help

GtoPdb Ligand ID: 5487

Synonyms: (+)-lansoprazol | (R)-lansoprazole | Dexilant SoluTab® | Dexilant® | Kapidex® | T 168390 | TAK 390
Approved drug
dexlansoprazole is an approved drug (FDA (2009); (1995 as lansoprazole))
Compound class: Synthetic organic
Comment: In addition to being an approved drug with INN dexlansoprazole, (R)-lansoprazole is also a component of the approved drug lansoprazole, a racemic mixture of (R)- and (S)- stereoisomers. Use this PubChem link to view all 3 isomers.

dexlansoprazole is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 87.08
Molecular weight 369.08
XLogP 1.89
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=S(c1nc2c([nH]1)cccc2)Cc1nccc(c1C)OCC(F)(F)F
Isomeric SMILES O=[S@@](c1nc2c([nH]1)cccc2)Cc1nccc(c1C)OCC(F)(F)F
InChI InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)/t25-/m1/s1
InChI Key MJIHNNLFOKEZEW-RUZDIDTESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2009)
IUPAC Name Click here for help
2-[(R)-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methane}sulfinyl]-1H-1,3-benzodiazole
International Nonproprietary Names Click here for help
INN number INN
8524 dexlansoprazole
6397 lansoprazole
Synonyms Click here for help
(+)-lansoprazol | (R)-lansoprazole | Dexilant SoluTab® | Dexilant® | Kapidex® | T 168390 | TAK 390
Database Links Click here for help
CAS Registry No. 138530-94-6
ChEBI CHEBI:6375
ChEMBL Ligand CHEMBL1201863
DrugBank Ligand DB00448
DrugCentral Ligand 4162
GtoPdb PubChem SID 178102134
PubChem CID 9578005
Search Google for chemical match using the InChIKey MJIHNNLFOKEZEW-RUZDIDTESA-N
Search Google for chemicals with the same backbone MJIHNNLFOKEZEW
Search PubMed clinical trials lansoprazole
Search PubMed titles lansoprazole
Search PubMed titles/abstracts lansoprazole
UniChem Compound Search for chemical match using the InChIKey MJIHNNLFOKEZEW-RUZDIDTESA-N
UniChem Connectivity Search for chemical match using the InChIKey MJIHNNLFOKEZEW-RUZDIDTESA-N
Wikipedia Dexlansoprazole, Lansoprazole

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
(R)-Lansoprazole (links to external site)
Cat. No. HY-13662B