Natural/Endogenous Targets
Target GPR39

Targets where the ligand is described in the comment field
Target	Comment
GPR39	Zn2+ has been reported to be a potent and efficacious agonist of human, mouse and rat GPR39 [4]. Obestatin (GHRL, Q9UBU3), a fragment from the ghrelin precursor, was reported initially as an endogenous ligand, but subsequent studies failed to reproduce these findings. GPR39 has been reported to be down-regulated in adipose tissue in obesity-related diabetes [1]. Gene disruption results in obesity and altered adipocyte metabolism [3]. Reviewed in [2].