FLICE-like inhibitory protein subunit p43   Click here for help

GtoPdb Ligand ID: 5188

Abbreviated name: FLIP subunit p43
Synonyms: CASP8 and FADD-like apoptosis regulator subunit p43
Compound class: Endogenous peptide in human, mouse or rat
Comment: This is the long isoform of cFLIP (c-FLIPL). It is acts as a death receptor inhibitor, by antagonising procaspase-8 incorporation into the death-inducing signaling complex (DISC), with an antiapoptotic effect. CRISPR-mediated knockout induces senolysis in senescent cancer cells [1].
Species: Human
Is a component of
FLICE-like inhibitory protein
Peptide Sequence Click here for help
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVE
THLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIH
RIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIP
EERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQS
VYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVD