FLICE-like inhibitory protein subunit p43   Click here for help

GtoPdb Ligand ID: 5188

Abbreviated name: FLIP subunit p43
Synonyms: CASP8 and FADD-like apoptosis regulator subunit p43
Compound class: Endogenous peptide in human, mouse or rat
Comment: This is the long isoform of cFLIP (c-FLIPL). It is acts as a death receptor inhibitor, by antagonising procaspase-8 incorporation into the death-inducing signaling complex (DISC), with an antiapoptotic effect. CRISPR-mediated knockout induces senolysis in senescent cancer cells [1].
Species: Human

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Related Sequences Click here for help
FLICE-like inhibitory protein subunit p12  {Sp: Human}