FLICE-like inhibitory protein subunit p43

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Ligands
FLICE-like inhibitory protein subunit p43 (Human)

GtoPdb Ligand ID: 5188

Abbreviated name: FLIP subunit p43

Synonyms: CASP8 and FADD-like apoptosis regulator subunit p43

Compound class: Endogenous peptide in human, mouse or rat

Comment: This is the long isoform of cFLIP (c-FLIPL). It is acts as a death receptor inhibitor, by antagonising procaspase-8 incorporation into the death-inducing signaling complex (DISC), with an antiapoptotic effect. CRISPR-mediated knockout induces senolysis in senescent cancer cells [1].

Species: Human

Summary
Biological activity
References
Structure
Similar ligands

References
1. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A et al.. (2022) cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis. Nat Cancer, 3 (11): 1284-1299. [PMID:36414711]

References

1. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A et al.. (2022)
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Nat Cancer, 3 (11): 1284-1299. [PMID:36414711]