FLICE-like inhibitory protein subunit p43   Click here for help

GtoPdb Ligand ID: 5188

Abbreviated name: FLIP subunit p43
Synonyms: CASP8 and FADD-like apoptosis regulator subunit p43
Compound class: Endogenous peptide in human, mouse or rat
Comment: This is the long isoform of cFLIP (c-FLIPL). It is acts as a death receptor inhibitor, by antagonising procaspase-8 incorporation into the death-inducing signaling complex (DISC), with an antiapoptotic effect. CRISPR-mediated knockout induces senolysis in senescent cancer cells [1].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
CASP8 and FADD-like apoptosis regulator subunit p43
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CFLAR CASP8 and FADD like apoptosis regulator Human prepro-CASP8 and FADD-like apoptosis regulator CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, Casper, c-FLIP, CLARP, FLAME, FLIP, I-FLICE, MRIT
Database Links Click here for help
Ensembl Gene ENSG00000003402 (Hs)
GtoPdb PubChem SID 178101876
Human Protein Atlas ENSG00000003402 (Hs)
UniProtKB O15519 (Hs)