- Guide to PHARMACOLOGY
Synonyms: Duodopa® | Lodosyn® | MK 486 
carbidopa is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Carbidopa was originally approved by the FDA in combination with levodopa in 1975. It is an inhibitor of L-Aromatic amino-acid decarboxylase (a.k.a. L-Dopa decarboxylase) [1,4] that decreases the peripheral decarboxylation of levodopa to dopamine. The competitive or noncompetitive nature of carbidopa's interaction with L-Dopa decarboxylase is complex. Two published papers that discuss the kinetics of the inhibitor/enzyme interaction are  and , and from analysis of these it would appear that due to the slow dissociation of carbidopa from L-Dopa decarboxylase, once the enzyme/inhibitor complex has formed substrate is unable to displace the inhibitor. Carbidopa is described as a competitive inhibitor in these articles [2-3].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: carbidopa
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1977))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Duodopa® | Lodosyn® | MK 486 |
|CAS Registry No.||28860-95-9|
|GtoPdb PubChem SID||178101851|
|RCSB PDB Ligand||142|
|Search Google for chemical match using the InChIKey||TZFNLOMSOLWIDK-JTQLQIEISA-N|
|Search Google for chemicals with the same backbone||TZFNLOMSOLWIDK|
|Search PubMed clinical trials||carbidopa|
|Search PubMed titles||carbidopa|
|Search PubMed titles/abstracts||carbidopa|
|UniChem Compound Search for chemical match using the InChIKey||TZFNLOMSOLWIDK-JTQLQIEISA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||TZFNLOMSOLWIDK-JTQLQIEISA-N|
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.✖
(S)-(-)-Carbidopa (links to external site)
Cat. No. 0455