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tumour necrosis factor membrane form   Click here for help

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species: Human
Natural/Endogenous Targets
Target
tumor necrosis factor receptor 1
tumor necrosis factor receptor 2
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
tumor necrosis factor receptor 1 Ligand is endogenous in the given species Hs None - - - -
⤷
tumor necrosis factor receptor 2 Ligand is endogenous in the given species Hs None - - - -
⤷