thrombopoietin   Click here for help

GtoPdb Ligand ID: 5063

Comment: This is the endogenous ligand of the thrombopoietin receptor. It promotes proliferation of megakaryocytic cells, which leads to increased platelet production. Human TPO is not used therapeutically as it is associated with a risk of immunogenicity and the development of neutralizing anti-TPO antibodies [1-2]. As a result of this outcome small molecule TPO receptor agonists have been developed to mimic the platelet-promoting action of native TPO.
Species: Human
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: thrombopoietin

Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
THPO thrombopoietin Human prepro-thrombopoietin c-mpl ligand, megakaryocyte colony-stimulating factor, megakaryocyte growth and development factor, megakaryocyte stimulating factor, MGDF, MPLLG, MPL ligand, myeloproliferative leukemia virus oncogene ligand, thrombopoietin nirs variant 1, TPO
Database Links Click here for help
Ensembl Gene ENSG00000090534 (Hs)
GtoPdb PubChem SID 178101756
Human Protein Atlas ENSG00000090534 (Hs)
UniProtKB P40225 (Hs)
Wikipedia Thrombopoietin