silodosin   Click here for help

GtoPdb Ligand ID: 493

Synonyms: KMD-3213 | Rapaflo® | Silodyx®
Approved drug
silodosin is an approved drug (FDA (2008), EMA (2010))
Compound class: Synthetic organic
Comment: Silodosin an α1-adrenoceptor antagonist with selectivity for prostate adrenoceptors (mainly the α1A subtype).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 97.05
Molecular weight 495.23
XLogP 3.66
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCCCN1CCc2c1c(cc(c2)CC(NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N
Isomeric SMILES OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N
InChI InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
InChI Key PNCPYILNMDWPEY-QGZVFWFLSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2008), EMA (2010))
IUPAC Name Click here for help
1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
International Nonproprietary Names Click here for help
INN number INN
8043 silodosin
Synonyms Click here for help
KMD-3213 | Rapaflo® | Silodyx®
Database Links Click here for help
Specialist databases
GPCRdb Ligand silodosin
Other databases
BindingDB Ligand 50160154
CAS Registry No. 160970-54-7 (source: Scifinder)
ChEMBL Ligand CHEMBL24778
DrugBank Ligand DB06207
DrugCentral Ligand 4151
GtoPdb PubChem SID 135650458
PubChem CID 5312125
Search Google for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
Search Google for chemicals with the same backbone PNCPYILNMDWPEY
Search PubMed clinical trials silodosin
Search PubMed titles silodosin
Search PubMed titles/abstracts silodosin
UniChem Compound Search for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
UniChem Connectivity Search for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
Wikipedia Silodosin

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Tocris
Silodosin (links to external site)
Cat. No. 6663