M-CSF

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Ligands
M-CSF (Human)

GtoPdb Ligand ID: 4905

Synonyms: CSF-1 | lanimostim | macrophage-CSF

Compound class: Endogenous peptide in human, mouse or rat

Comment: M-CSF (CSF1) controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.

Species: Human

No information available.

No information available.

Summary of Clinical Use
An eye drop formulation containing CSF1 (PresbiDrops; Orasis Pharmaceuticals) is in clinical development for presbyopia, an age-related condition that causes long-sightedness.

Summary of Clinical Use

An eye drop formulation containing CSF1 (PresbiDrops; Orasis Pharmaceuticals) is in clinical development for presbyopia, an age-related condition that causes long-sightedness.

Clinical Trials
Clinical Trial ID	Title	Type	Source	Comment	References
NCT02965664	Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects	Phase 2 Interventional	Orasis Pharmaceuticals Ltd.
NCT03885011	A Multi-Center, Double-Masked Evaluation of the Efficacy and Safety of CSF-1 in the Treatment of Presbyopia	Phase 2 Interventional	Orasis Pharmaceuticals Ltd.