brain natriuretic peptide   Click here for help

GtoPdb Ligand ID: 4890

Abbreviated name: BNP
Synonyms: BNP(1-32) | BNP-32 | brain natriuretic peptide 32 | Natrecor®
Approved drug
brain natriuretic peptide is an approved drug (FDA (2001))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Nesiritide is the recombinant form of human brain natriuretic peptide.
Species: Human
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Bioactivity Comments
There appears to be no publicly available bioactivity data for this drug at its human molecular target.
Natural/Endogenous Targets
Target
Guanylyl cyclase-A
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Guanylyl cyclase-A Ligand is endogenous in the given species Hs Agonist Binding - - - 1
⤷ [1]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order at Guanylyl cyclase-A atrial natriuretic peptide (NPPA, P01160) ≥ brain natriuretic peptide (NPPB, P16860) >> C-type natriuretic peptide (NPPC, P23582) 2
Potency order at Guanylyl cyclase-B C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860) 2
Potency order at natriuretic peptide receptor 3 atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860) 2