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growth/differentiation factor-11   Click here for help

GtoPdb Ligand ID: 4876

Synonyms: BMP11 | bone morphogenetic protein 11 | GDF-11
Compound class: Endogenous peptide in human, mouse or rat
Comment: The active peptide is a disulphide bond-linked homodimer
Species: Human
Natural/Endogenous Targets
Target
activin A receptor type 1B
activin A receptor type 1C
transforming growth factor beta receptor 1
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
luspatercept Peptide Approved drug Hs Fusion protein Binding 10.1 pKd - 1
⤷ pKd 10.1 (Kd 7.4x10-11 M) [1]
Description: Binding to GDF11 determined by surface plasmon resonance (SPR).