XCL1   Click here for help

GtoPdb Ligand ID: 3647

Synonyms: c motif cytokine 1 | cytokine SCM-1α | lymphotactin α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: XCL1 is a C class chemokine also known as lymphotactin.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Blaschke S, Middel P, Dorner BG, Blaschke V, Hummel KM, Kroczek RA, Reich K, Benoehr P, Koziolek M, Müller GA. (2003)
Expression of activation-induced, T cell-derived, and chemokine-related cytokine/lymphotactin and its functional role in rheumatoid arthritis.
Arthritis Rheum, 48 (7): 1858-72. [PMID:12847680]
2. Bradley LM, Asensio VC, Schioetz LK, Harbertson J, Krahl T, Patstone G, Woolf N, Campbell IL, Sarvetnick N. (1999)
Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes.
J Immunol, 162 (5): 2511-20. [PMID:10072490]
3. Fox JC, Nakayama T, Tyler RC, Sander TL, Yoshie O, Volkman BF. (2015)
Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.
Cytokine, 71 (2): 302-11. [PMID:25497737]
4. Lei Y, Takahama Y. (2012)
XCL1 and XCR1 in the immune system.
Microbes Infect, 14 (3): 262-7. [PMID:22100876]
5. Middel P, Thelen P, Blaschke S, Polzien F, Reich K, Blaschke V, Wrede A, Hummel KM, Gunawan B, Radzun HJ. (2001)
Expression of the T-cell chemoattractant chemokine lymphotactin in Crohn's disease.
Am J Pathol, 159 (5): 1751-61. [PMID:11696436]