angiotensin II   Click here for help

GtoPdb Ligand ID: 2504

Synonyms: ang II | Giapreza®
Approved drug
angiotensin II is an approved drug (FDA (2017))
Comment: Endogenous angiotensin II is a vasopressor.
Species: Human, Mouse, Rat
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2D Structure
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Canonical SMILES CCC(C(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
Isomeric SMILES CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
InChI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Approved drug? Yes (FDA (2017))
IUPAC Name Click here for help
(3S)-3-amino-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
International Nonproprietary Names Click here for help
INN number INN
6707 angiotensin II
Synonyms Click here for help
ang II | Giapreza®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
AGT angiotensinogen Human Angiotensinogen alpha-1 antiproteinase, antitrypsin, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), SERPINA8
Agt angiotensinogen Mouse Angiotensinogen angiotensinogen (serpin peptidase inhibitor, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), angiotensin precursor, Aogen, Serpina8
Agt angiotensinogen Rat Angiotensinogen Ang, AngII, angiotensin II, angiotensinogen, angiotensinogen (PAT), angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANRT, MGC105326, PAT, serpin A8
Database Links Click here for help
Specialist databases
GPCRdb Ligand angiotensin II
Other databases
BindingDB Ligand 82077
CAS Registry No. 4474-91-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL408403
DrugCentral Ligand 5272
Ensembl Gene ENSG00000135744 (Hs), ENSRNOG00000018445 (Rn)
GtoPdb PubChem SID 53801076
Human Protein Atlas ENSG00000135744 (Hs)
PubChem CID 172198
Search Google for chemical match using the InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Search Google for chemicals with the same backbone CZGUSIXMZVURDU
Search PubMed clinical trials angiotensin II
Search PubMed titles angiotensin II
Search PubMed titles/abstracts angiotensin II
UniChem Compound Search for chemical match using the InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
UniChem Connectivity Search for chemical match using the InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
UniProtKB P01015 (Rn), P11859 (Mm), P01019 (Hs)
Wikipedia Angiotensin_II#Angiotensin_II

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Angiotensin II (links to external site)
Cat. No. 1158