prucalopride   Click here for help

GtoPdb Ligand ID: 243

Synonyms: Motegrity® | R-093877 | R-108512 | Resolor®
Approved drug
prucalopride is an approved drug (EMA (2009), FDA (2018))
Compound class: Synthetic organic
Comment: Prucalopride is a serotonin 5-HT4 receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 76.82
Molecular weight 367.17
XLogP 1.56
No. Lipinski's rules broken 0
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Canonical SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
Isomeric SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2009), FDA (2018))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7702 prucalopride
Synonyms Click here for help
Motegrity® | R-093877 | R-108512 | Resolor®
Database Links Click here for help
Specialist databases
GPCRdb Ligand prucalopride
Other databases
BindingDB Ligand 50122872
CAS Registry No. 179474-81-8 (source: Scifinder)
ChEMBL Ligand CHEMBL117287
DrugCentral Ligand 3502
GtoPdb PubChem SID 135650861
PubChem CID 3052762
Search Google for chemical match using the InChIKey ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZPMNHBXQOOVQJL
Search PubMed clinical trials prucalopride
Search PubMed titles prucalopride
Search PubMed titles/abstracts prucalopride
UniChem Compound Search for chemical match using the InChIKey ZPMNHBXQOOVQJL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Wikipedia Prucalopride