Synonyms: CI 977 | CI-977 | CI977
Compound class:
Synthetic organic
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Hjorth SA, Thirstrup K, Schwartz TW. (1996)
Radioligand-dependent discrepancy in agonist affinities enhanced by mutations in the kappa-opioid receptor. Mol Pharmacol, 50 (4): 977-84. [PMID:8863844] |
2. Hunter JC, Leighton GE, Meecham KG, Boyle SJ, Horwell DC, Rees DC, Hughes J. (1990)
CI-977, a novel and selective agonist for the kappa-opioid receptor. Br J Pharmacol, 101 (1): 183-9. [PMID:2178014] |
3. Neumeyer JL, Zhang A, Xiong W, Gu XH, Hilbert JE, Knapp BI, Negus SS, Mello NK, Bidlack JM. (2003)
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. J Med Chem, 46 (24): 5162-70. [PMID:14613319] |