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SD-965   Click here for help

GtoPdb Ligand ID: 14452

Synonyms: compound 27 [PMID: 41871272] | SD965
Compound class: Synthetic organic
Comment: SD-965 is reported as signal transducer and activator of transcription 3 (STAT3) PROTAC degrader [1]. It is active in in vitro and in vivo cancer models. It incorporates a high affinity cereblon (CRBN) ligand to engage the E3 ubiquitin ligase, and an optimised ligand to interact with STAT3.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 27
Hydrogen bond donors 7
Rotatable bonds 23
Topological polar surface area 389.36
Molecular weight 1213.21
XLogP -3.27
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CS(=O)(=O)C1=CC(=CC=C1)OC[C@H](CCC(=O)N)NC(=O)[C@@H]2CC[C@@H]3CCN(C[C@@H](C(=O)N32)NC(=O)C4=CC5=C(C=CC(=C5)C(=O)P(=O)(O)O)N4)C(=O)CCCCC(=O)N6CCN7[C@H](C6)COC8=C9CN([C@H]%10CCC(=O)NC%10=O)C(=O)C9=CC=C87
Isomeric SMILES O=C1N([C@H]2CCC(NC2=O)=O)CC3=C4C(N5[C@@H](CO4)CN(C(CCCCC(N6C[C@H](NC(C7=CC=8C=C(C(P(O)(O)=O)=O)C=CC8N7)=O)C(N9[C@H](C(N[C@H](COC%10=CC(S(=O)(C)=O)=CC=C%10)CCC(N)=O)=O)CC[C@@H]9CC6)=O)=O)=O)CC5)=CC=C31
InChI InChI=1S/C56H65N10O17PS/c1-85(80,81)37-6-4-5-36(25-37)82-29-33(10-17-46(57)67)58-53(73)45-14-11-34-19-20-62(28-42(55(75)66(34)45)60-51(71)41-24-32-23-31(9-13-40(32)59-41)56(76)84(77,78)79)48(69)7-2-3-8-49(70)63-21-22-64-35(26-63)30-83-50-39-27-65(44-16-18-47(68)61-52(44)72)54(74)38(39)12-15-43(50)64/h4-6,9,12-13,15,23-25,33-35,42,44-45,59H,2-3,7-8,10-11,14,16-22,26-30H2,1H3,(H2,57,67)(H,58,73)(H,60,71)(H,61,68,72)(H2,77,78,79)/t33-,34+,35+,42-,44-,45-/m0/s1
InChI Key QQGBHHGKESADLH-JEACGVKKSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Wu D, Zhou H, Bai L, Acharyya RK, Metwally H, McEachern D, Wang M, Tošović J, Rej RK, Wang M et al.. (2026)
Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.
J Med Chem, 69 (7): 8364-8387. [PMID:41871272]