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aleniglipron   Click here for help

GtoPdb Ligand ID: 14436

Synonyms: compound 121a [WO2023016546] | GSBR-1290 | GSBR1001290 | GSBR1290
Compound class: Synthetic organic
Comment: Aleniglipron (GSBR1290; Structure Therapeutics/Gasherbrum Bio) is an oral, non-peptide GLP-1 full agonist [2]. Functionally, it is an orthosteric biased agonist that activates Gαs-cAMP signaling, with undetectable β-arrestin recruitment [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

aleniglipron is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 13
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 161.53
Molecular weight 915.99
XLogP 5.15
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCP(=O)(CC)C1=CC=C(C=C1NC)N2C=CN(C3=C4[C@H](C)N(CCC4=NN3C5=CC(=C(C(=C5)C)F)C)C(=O)C6=CC7=C(C=CC(=C7)C8CCOCC8)N6[C@]9(C[C@@H]9C)C%10=NOC(=O)N%10)C2=O
Isomeric SMILES CCP(=O)(CC)C1=C(C=C(C=C1)N2C=CN(C2=O)C3=C4[C@@H](N(CCC4=NN3C5=CC(=C(C(=C5)C)F)C)C(=O)C6=CC7=C(N6[C@]8(C[C@@H]8C)C9=NOC(=O)N9)C=CC(=C7)C%10CCOCC%10)C)NC
InChI InChI=1S/C49H55FN9O6P/c1-8-66(63,9-2)41-13-11-35(26-38(41)51-7)56-18-19-57(48(56)62)44-42-31(6)55(17-14-37(42)53-59(44)36-22-28(3)43(50)29(4)23-36)45(60)40-25-34-24-33(32-15-20-64-21-16-32)10-12-39(34)58(40)49(27-30(49)5)46-52-47(61)65-54-46/h10-13,18-19,22-26,30-32,51H,8-9,14-17,20-21,27H2,1-7H3,(H,52,54,61)/t30-,31-,49-/m0/s1
InChI Key CPOJUYUGONJVPZ-WIXASUBBSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
Aleniglipron (GSBR1290) was progressed as a clinical candidate for overweight/obesity and type 2 diabetes.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05893043 A Study of Multiple Ascending Doses of GSBR-1290 in Japanese and Non-Japanese Healthy Participants Phase 1 Interventional Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT05762471 Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus Phase 1/Phase 2 Interventional Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT07169942 Aleniglipron Phase 2 Body Composition Study Phase 2 Interventional Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT06703021 A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity Phase 2 Interventional Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics