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sepiapterin   Click here for help

GtoPdb Ligand ID: 14278

Synonyms: CNSA-001 [1] | L-sepiapterin | PTC-923 | PTC923 | Sephience®
Approved drug
sepiapterin is an approved drug
Compound class: Synthetic organic
Comment: Sepiapterin (PTC923) is an orally bioavailable phenylalanine hydroxylase (PAH) activator. It is a precursor of the PAH cofactor BH4 (tetrahydrobiopterin/sapropterin).

sepiapterin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 129.17
Molecular weight 237.22
XLogP -0.67
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[C@@H](C(=O)C1=NC2=C(NC1)NC(=NC2=O)N)O
Isomeric SMILES O=C1C2=C(NCC(C([C@H](C)O)=O)=N2)NC(N)=N1
InChI InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
InChI Key VPVOXUSPXFPWBN-VKHMYHEASA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (2025)  |  US FDA (2025)
Is prodrug? Yes
Active form sapropterin
IUPAC Name Click here for help
2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-3H-pteridin-4-one
International Nonproprietary Names Click here for help
INN number INN
11848 sepiapterin
Synonyms Click here for help
CNSA-001 [1] | L-sepiapterin | PTC-923 | PTC923 | Sephience®
Database Links Click here for help
ChEBI CHEBI:16095
ChEMBL Ligand CHEMBL1255653
GtoPdb PubChem SID 521588918
PubChem CID 135398579
Search Google for chemical match using the InChIKey VPVOXUSPXFPWBN-VKHMYHEASA-N
Search Google for chemicals with the same backbone VPVOXUSPXFPWBN
Search PubMed clinical trials sepiapterin
Search PubMed titles sepiapterin
Search PubMed titles/abstracts sepiapterin
UniChem Compound Search for chemical match using the InChIKey VPVOXUSPXFPWBN-VKHMYHEASA-N
UniChem Connectivity Search for chemical match using the InChIKey VPVOXUSPXFPWBN-VKHMYHEASA-N

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MedChemExpress
L-Sepiapterin (links to external site)
Cat. No. HY-112234