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soclenicant   Click here for help

GtoPdb Ligand ID: 14250

Synonyms: BNC-210 | IW-2143 | L-isoleucyl-L-tryptophan
Compound class: Synthetic organic
Comment: Soclenicant (BNC210; formerly IW-2143) is an α7 nicotinic acetylcholine receptor negative allosteric modulator [4]. It was proposed for the treatment of psychiatric conditions [1-2,5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 74.24
Molecular weight 418.49
XLogP 1.19
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCN1C=C(C(=O)C2=CC(=CN=C21)NC3CC4=C(C=CC=C4)C3)C(=O)N5CCOCC5
Isomeric SMILES CCN1C=C(C(=O)C2=C1N=CC(=C2)NC3CC4=CC=CC=C4C3)C(=O)N5CCOCC5
InChI InChI=1S/C24H26N4O3/c1-2-27-15-21(24(30)28-7-9-31-10-8-28)22(29)20-13-19(14-25-23(20)27)26-18-11-16-5-3-4-6-17(16)12-18/h3-6,13-15,18,26H,2,7-12H2,1H3
InChI Key ZAEIHDZLLJCJFP-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
Soclenicant (BNC210) was advanced to clinical studies to evaluate safety and efficacy as a treatment for anxiety disorders. Neuphoria Therapeutics discontinued the soclenicant social anxiety disorder program in October 2025, due to lack of efficacy (compared to placebo) in the phase 3 AFFIRM-1 study in trial participants with social anxiety. Soclenicant administration failed to meet the study's predetermined primary or secondary endpoints.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02933606 Phase II Study of BNC210 in PTSD Phase 2 Interventional Bionomics Limited
NCT03548194 A Study of BNC210 in Elderly Patients With Agitation Phase 2 Interventional Bionomics Limited
NCT05193409 A Phase 2 Study of BNC210 for the Acute Treatment of Social Anxiety Disorder Phase 2 Interventional Bionomics Limited
NCT06510504 Efficacy of BNC210 in Acute, As-needed Treatment of Anxiety in Social Anxiety Disorder - 1 Phase 3 Interventional Bionomics Limited
NCT04951076 A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD) Phase 2 Interventional Bionomics Limited The ATTUNE study 3