TYD-68   Click here for help

GtoPdb Ligand ID: 13823

Synonyms: TYK2 PROTAC 15t [PMID: 40116635]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: TYD-68 is a cereblon-recruiting PROTAC that promotes selective degradation of tyrosine kinase 2 (TYK2) [1]. It is a heterobifunctional molecule that binds to the allosteric pseudokinase domain (Janus homology 2: JH2) of TYK2 (using a BMS-986202 derivative) and to cereblon.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 18
Hydrogen bond donors 6
Rotatable bonds 14
Topological polar surface area 236.51
Molecular weight 841.85
XLogP -0.79
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CNC(=O)C1=C(C=C(N=C1)NC2=CC=C(C=N2)C(=O)NC3CCC(CC3)NC4=CC=C5C(=C4)C(=O)N(C6CCC(=O)NC6=O)C5=O)NC7=CC=CC(=C7OC)C8=NC=C(C=N8)F
Isomeric SMILES COC1=C(NC2=CC(NC3=CC=C(C(NC4CCC(NC5=CC6=C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)C=C5)CC4)=O)C=N3)=NC=C2C(NC)=O)C=CC=C1C8=NC=C(F)C=N8
InChI InChI=1S/C43H40FN11O7/c1-45-40(58)30-21-47-35(17-32(30)52-31-5-3-4-28(37(31)62-2)38-48-19-23(44)20-49-38)53-34-14-6-22(18-46-34)39(57)51-25-9-7-24(8-10-25)50-26-11-12-27-29(16-26)43(61)55(42(27)60)33-13-15-36(56)54-41(33)59/h3-6,11-12,14,16-21,24-25,33,50H,7-10,13,15H2,1-2H3,(H,45,58)(H,51,57)(H,54,56,59)(H2,46,47,52,53)
InChI Key NKSVQPQJZWJRLO-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Xiong S, Yang J, Yang M, Xiao M, Ha S, Tao W, Ma L, Ji C, Xiang H, Luo G. (2025)
Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model.
J Med Chem, [Epub ahead of print]. [PMID:40116635]