C6-Quino   Click here for help

GtoPdb Ligand ID: 13817

Compound class: Synthetic organic
Comment: C6-Quino is a naltrindole derivative. It has been optimised as a biased partial agonist of the δ opioid receptor [1]. It interacts with the orthosteric binding site and with the receptor's allosteric sodium binding pocket. C6-Quino demonstrates bias towards G protein signalling (preferentially recruiting Gi1) compared to β-arrestin recruitment. Antinociceptive activity has been observed in rodent models of chronic pain of various etiologies.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 127.19
Molecular weight 513.63
XLogP 1.05
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCCC(CCNC(=N)N)N1CC[C@]23C4=C5C(=CC=C4C[C@@H]1[C@@]3(CC6=CC7=C(C=CC=C7)N=C6[C@@H]2O5)O)O
Isomeric SMILES OC1=CC=C2C3=C1O[C@@H]4[C@@]35[C@@](CC=6C=C7C=CC=CC7=NC46)([C@H](N(CC5)C(CCNC(=N)N)CCC)C2)O
InChI InChI=1S/C30H35N5O3/c1-2-5-20(10-12-33-28(31)32)35-13-11-29-24-18-8-9-22(36)26(24)38-27(29)25-19(16-30(29,37)23(35)15-18)14-17-6-3-4-7-21(17)34-25/h3-4,6-9,14,20,23,27,36-37H,2,5,10-13,15-16H2,1H3,(H4,31,32,33)/t20?,23-,27+,29+,30-/m1/s1
InChI Key NNOQVDPTMMFENI-QDROEUSWSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Bioactivity Comments
Emax of C6-Quino at human δOR is 68% and at the mouse receptor Emax is 70% [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
δ receptor Hs Agonist Partial agonist 8.9 pKi - 1
⤷ pKi 8.9 (Ki 1.35x10-9 M) [1]
Description: Determined in a radioligand competition binding with 3H-DPDPE