darlifarnib   Click here for help

GtoPdb Ligand ID: 13803

Synonyms: compound (S)-058 [US20230322711] | KO-2806 | KO2806
Compound class: Synthetic organic
Comment: We have matched the chemical structure for the INN darlifarnib to Kura Oncology's farnesyl transferase inhibitor clinical candidate KO-2806 [1]. The structure is one of those claimed in patent US20230322711A1 [2]. KO-2806 is proposed as an agent for use in combination with RAS inhibitors, to overcome resistance to these drugs. KO-2806 functions to inhibit farnesylation and subsequent activation of mTORC1 [1]. It will also block farnesylation of the CAAX motif on RAS oncogenes that is essential for RAS anchoring to the cell membrane where (proliferative) RAS extracellular signals are transduced [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 110.79
Molecular weight 468.51
XLogP 0.23
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN1C=NC=C1[C@]2(C3=CC=C(C#N)C(=C3)COC4=CC=CC(=C4)C5=CC(=NC6=C5C=C2C=C6)C#N)N
Isomeric SMILES CN1C=NC=C1[C@]2(C3=CC(=C(C=C3)C#N)COC4=CC=CC(=C4)C5=C6C=C2C=CC6=NC(=C5)C#N)N
InChI InChI=1S/C29H20N6O/c1-35-17-33-15-28(35)29(32)21-6-5-19(13-30)20(9-21)16-36-24-4-2-3-18(10-24)25-12-23(14-31)34-27-8-7-22(29)11-26(25)27/h2-12,15,17H,16,32H2,1H3/t29-/m1/s1
InChI Key GWKGWWBQKOIPNP-GDLZYMKVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
International Nonproprietary Names Click here for help
INN number INN
13470 darlifarnib
Synonyms Click here for help
compound (S)-058 [US20230322711] | KO-2806 | KO2806
Database Links Click here for help
CAS Registry No. 2939824-30-1 (source: WHO INN record)
GtoPdb PubChem SID 507750436
PubChem CID 169292289
Search Google for chemical match using the InChIKey GWKGWWBQKOIPNP-GDLZYMKVSA-N
Search Google for chemicals with the same backbone GWKGWWBQKOIPNP
Search PubMed clinical trials darlifarnib
Search PubMed titles darlifarnib
Search PubMed titles/abstracts darlifarnib
UniChem Compound Search for chemical match using the InChIKey GWKGWWBQKOIPNP-GDLZYMKVSA-N
UniChem Connectivity Search for chemical match using the InChIKey GWKGWWBQKOIPNP-GDLZYMKVSA-N