BRINP2-related peptide

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Ligands
BRINP2-related peptide (Human)

GtoPdb Ligand ID: 13788

Synonyms: BRP

Compound class: Endogenous peptide in human, mouse or rat

Comment: BRP is a bioactive 12 amino acid peptide that is predicted to be cleaved from the BMP/retinoic acid-inducible neural-specific protein 2 (BRINP2) precursor by prohormone convertase 1 (PCSK1) activity [1]. C-terminal amidation (NH₂) and the Leu8 residue are essential for bioactivity. The peptide is proposed to engage a Gα_s-coupled GPCR (in neuronal cells) to mediate its effects on the CREB-FOS signalling pathway (as CREB phosphorylation was sensitive to melittin but insensitive to pertussis toxin and YM254890). The GPCR has not been identified (March 2025).

Species: Human

Bioactivity Comments
BRP was detected in mouse brain and in human cerebrospinal fluid. In vitro BRP increases Fos expression more potently than glucagon-like peptide 1-(7-37) (GLP-1_7-37), and activates the cAMP-PKA-CREB-FOS pathway. Administration of the peptide in animal models is anorexigenic and combats obesity, via a mechanism that is independent of leptin, and the GLP-1 and melanocortin 4 receptors [1].

Bioactivity Comments

BRP was detected in mouse brain and in human cerebrospinal fluid. In vitro BRP increases Fos expression more potently than glucagon-like peptide 1-(7-37) (GLP-1_7-37), and activates the cAMP-PKA-CREB-FOS pathway. Administration of the peptide in animal models is anorexigenic and combats obesity, via a mechanism that is independent of leptin, and the GLP-1 and melanocortin 4 receptors [1].