BRINP2-related peptide   Click here for help

GtoPdb Ligand ID: 13788

Synonyms: BRP
Compound class: Endogenous peptide in human, mouse or rat
Comment: BRP is a bioactive 12 amino acid peptide that is predicted to be cleaved from the BMP/retinoic acid-inducible neural-specific protein 2 (BRINP2) precursor by prohormone convertase 1 (PCSK1) activity [1]. C-terminal amidation (NH2) and the Leu8 residue are essential for bioactivity. The peptide is proposed to engage a Gαs-coupled GPCR (in neuronal cells) to mediate its effects on the CREB-FOS signalling pathway (as CREB phosphorylation was sensitive to melittin but insensitive to pertussis toxin and YM254890). The GPCR has not been identified (March 2025).
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
BRP
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
BRINP2 BMP/retinoic acid inducible neural specific 2 Human BMP/retinoic acid-inducible neural-specific protein 2 precursor -
Database Links Click here for help
GtoPdb PubChem SID 507750421