annexin A3   Click here for help

GtoPdb Ligand ID: 13777

Synonyms: annexin III | calcimedin 35-alpha | inositol 1,2-cyclic phosphate 2-phosphohydrolase (EC 3.1.4.43) | lipocortin III | placental anticoagulant protein III
Compound class: Endogenous peptide in human, mouse or rat
Comment: Annexin A3 (ANXA3) is one member of a family of intracellular calcium-dependent phospholipid-binding proteins (13 genes in humans). It regulates cellular growth and signal transduction pathways via inhibition of phopholipase A2. This activity modulates the conversion of inositol 1,2-cyclic phosphate to inositol 1-phosphate.
Pathogenic effects of ANXA3 have been reported in the development of cancers [2,4], in particular triple-negative breast cancer (TNBC) [5]. Pharmacological modulation of ANXA3 is therefore of interest for the development of TNBC therapeutics.
Species: Human
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
ANXA3 degrader 18a5 Small molecule or natural product Hs None Binding 7.4 pKd - 3
⤷ pKd 7.4 (Kd 4x10-8 M) [3]
Description: Binding affinity for annexin A3, detemined by SPR
ANXA3 degrader (R)-SL18 Small molecule or natural product Hs None Binding 6.2 – 6.3 pKd - 1
⤷ pKd 6.3 (Kd 5.2x10-7 M) [1]
Description: Binding affinity for ANXA3 determined by ITC
pKd 6.2 (Kd 5.8x10-7 M) [1]
Description: Binding affinity for ANXA3 determined by SPR