acyl-CoA-binding protein

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Ligands
acyl-CoA-binding protein (Human)

GtoPdb Ligand ID: 13696

Synonyms: endozepine [6]

Compound class: Endogenous peptide in human, mouse or rat

Comment: Diazepam binding inhibitor/Acyl-CoA-binding protein (ACBP) an a 11kD peptide with multiple biological actions [1,3,5]. It is reported to bind to thiol esters of long fatty acids and coenzyme A. It also displaces diazepam from the benzodiazepine binding domain of type A gamma-aminobutyric acid GABA_A receptors [2,4], which suggests that it may act as an allosteric GABA_A modulator.

Species: Human

References
1. Costa E, Guidotti A. (1991) Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Life Sci, 49 (5): 325-44. [PMID:1649940]
2. Gersuk VH, Rose TM, Todaro GJ. (1995) Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor. Genomics, 25 (2): 469-76. [PMID:7789980]
3. Gray PW. (1987) Molecular biology of diazepam binding inhibitor. Neuropharmacology, 26 (7B): 863-5. [PMID:2821429]
4. Gray PW, Glaister D, Seeburg PH, Guidotti A, Costa E. (1986) Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor. Proc Natl Acad Sci U S A, 83 (19): 7547-51. [PMID:3020548]
5. Mocchetti I. (1990) Molecular biology of diazepam binding inhibitor peptide. Neurochem Res, 15 (2): 125-30. [PMID:2185430]
6. Todaro GJ, Rose TM, Shoyab M. (1991) Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI). Neuropharmacology, 30 (12B): 1373-80. [PMID:1780036]

References

1. Costa E, Guidotti A. (1991)
Diazepam binding inhibitor (DBI): a peptide with multiple biological actions.
Life Sci, 49 (5): 325-44. [PMID:1649940]

2. Gersuk VH, Rose TM, Todaro GJ. (1995)
Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor.
Genomics, 25 (2): 469-76. [PMID:7789980]

3. Gray PW. (1987)
Molecular biology of diazepam binding inhibitor.
Neuropharmacology, 26 (7B): 863-5. [PMID:2821429]

4. Gray PW, Glaister D, Seeburg PH, Guidotti A, Costa E. (1986)
Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.
Proc Natl Acad Sci U S A, 83 (19): 7547-51. [PMID:3020548]

5. Mocchetti I. (1990)
Molecular biology of diazepam binding inhibitor peptide.
Neurochem Res, 15 (2): 125-30. [PMID:2185430]

6. Todaro GJ, Rose TM, Shoyab M. (1991)
Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI).
Neuropharmacology, 30 (12B): 1373-80. [PMID:1780036]