tulathromycin   Click here for help

GtoPdb Ligand ID: 13691

Synonyms: Draxxin® (veterinary) | tulathromycin A
Compound class: Synthetic organic
Comment: Tulathromycin is a macrolide (triamilide subclass) antibacterial that was developed for use in veterinary medicine [3]. It consists of an equilibrated mixture of a 15-membered and a 13-membered ring component in a 9:1 ratio [2]. We show the structure for tulathromycin A, the 15-membered isomer.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 15
Hydrogen bond donors 7
Rotatable bonds 11
Topological polar surface area 200.9
Molecular weight 806.08
XLogP 2.47
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCCNC[C@@]1([C@H](C)O[C@H](C[C@@]1(C)OC)O[C@H]2[C@H](C)[C@H]([C@@](C)(C[C@@H](C)CN[C@H](C)[C@H]([C@@](C)([C@@H](CC)OC(=O)[C@@H]2C)O)O)O)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)O
Isomeric SMILES CCCNC[C@@]1([C@@H](O[C@H](C[C@@]1(C)OC)O[C@H]2[C@@H]([C@H]([C@](C[C@H](CN[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]2C)CC)(C)O)O)C)C)(C)O)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)C)C)O
InChI InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27-,28+,29+,30-,31+,32-,33+,34-,35-,37+,38-,39-,40-,41+/m1/s1
InChI Key GUARTUJKFNAVIK-QPTWMBCESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S. (2012)
Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.
Antimicrob Agents Chemother, 56 (11): 6033-6. [PMID:22926570]
2. Gáler D, Hessong S, Beato B, Risk J, Inskeep P, Weerasinghe C, Schneider RP, Langer C, LaPerle J, Renouf D et al.. (2004)
An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung.
J Agric Food Chem, 52 (8): 2179-91. [PMID:15080618]
3. Norcia LJ, Silvia AM, Santoro SL, Retsema J, Letavic MA, Bronk BS, Lundy KM, Yang B, Evans NA, Hayashi SF. (2004)
In vitro microbiological characterization of a novel azalide, two triamilides and an azalide ketal against bovine and porcine respiratory pathogens.
J Antibiot (Tokyo), 57 (4): 280-8. [PMID:15217193]
4. Villarino N, Brown SA, Martín-Jiménez T. (2013)
The role of the macrolide tulathromycin in veterinary medicine.
Vet J, 198 (2): 352-7. [PMID:24268476]