manoalide   Click here for help

GtoPdb Ligand ID: 13677

Synonyms: MC-13 [6]
Compound class: Natural product
Comment: Manoalide is a sesterterpenoid compound that has been isolated from species of marine sponges such as Luffariella variabilis.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 75.99
Molecular weight 416.55
XLogP 4.42
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C/C(=C\CCC1=CC[C@H](C2=CC(=O)O[C@H]2O)O[C@H]1O)/CCC3=C(C)CCCC3(C)C
Isomeric SMILES CC1=C(C(CCC1)(C)C)CC/C(=C/CCC2=CC[C@@H](O[C@H]2O)C3=CC(=O)O[C@H]3O)/C
InChI InChI=1S/C25H36O5/c1-16(10-12-20-17(2)8-6-14-25(20,3)4)7-5-9-18-11-13-21(29-23(18)27)19-15-22(26)30-24(19)28/h7,11,15,21,23-24,27-28H,5-6,8-10,12-14H2,1-4H3/b16-7+/t21-,23-,24-/m1/s1
InChI Key FGJIDQWRRLDGDB-CPIXEKRISA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Dal Piaz F, Casapullo A, Randazzo A, Riccio R, Pucci P, Marino G, Gomez-Paloma L. (2002)
Molecular basis of phospholipase A2 inhibition by petrosaspongiolide M.
Chembiochem, 3 (7): 664-71. [PMID:12325001]
2. De Rosa S, Crispino A, De Giulio A, Iodice C, Benrezzouk R, Terencio MC, Ferrándiz ML, Alcaraz MJ, Payá M. (1998)
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
J Nat Prod, 61 (7): 931-5. [PMID:9677277]
3. Glaser KB, Jacobs RS. (1986)
Molecular pharmacology of manoalide. Inactivation of bee venom phospholipase A2.
Biochem Pharmacol, 35 (3): 449-53. [PMID:3947381]
4. Glaser KB, Jacobs RS. (1987)
Inactivation of bee venom phospholipase A2 by manoalide. A model based on the reactivity of manoalide with amino acids and peptide sequences.
Biochem Pharmacol, 36 (13): 2079-86. [PMID:3111475]
5. Glaser KB, Vedvick TS, Jacobs RS. (1988)
Inactivation of phospholipase A2 by manoalide. Localization of the manoalide binding site on bee venom phospholipase A2.
Biochem Pharmacol, 37 (19): 3639-46. [PMID:3178877]
6. Iobbi V, Parisi V, Giacomini M, De Riccardis F, Brun P, Nunez-Pons L, Drava G, Giordani P, Monti MC, Poggi R. (2025)
Sesterterpenoids: sources, structural diversity, biological activity, and data management.
Nat Prod Rep, Advance Article. DOI: 10.1039/D4NP00041B