manoalide [Ligand Id: 13677] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL463914 (Manoalide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| DNA polymerase kappa in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5365] [UniProtKB: Q9UBT6] | ||||||||
| ChEMBL | Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions preincubated for 15 mins followed by DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay | B | 5.25 | pIC50 | 5600 | nM | IC50 | J Med Chem (2016) 59: 9321-9336 [PMID:27362876] |
| ChEMBL | Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2016) 59: 9321-9336 [PMID:27362876] |
| Phospholipase A2 in Honeybee (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885667] [UniProtKB: B7UUK1] | ||||||||
| ChEMBL | Inhibition of bee venom PLA2 | B | 7.4 | pIC50 | 40 | nM | IC50 | J Nat Prod (1992) 55: 1701-1717 [PMID:1294693] |
| Phospholipase A2, acidic in Naja naja (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5584] [UniProtKB: P15445] | ||||||||
| ChEMBL | Inhibition of Naja naja venom group1 sPLA2 at 10 uM by liquid scintillation counting | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
| Phospholipase A2 alpha in Crotalus adamanteus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5711] [UniProtKB: P00623] | ||||||||
| ChEMBL | Inhibition of Crotalus adamanteus venom phospholipase A2 by fluorometric assay | B | 6.4 | pIC50 | 400 | nM | IC50 | J Nat Prod (2006) 69: 1676-1679 [PMID:17190441] |
| Phospholipase A2 (Bee) in Honeybee (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4807] [UniProtKB: P00630] | ||||||||
| ChEMBL | Inhibition of bee venom group3 sPLA2 at 10 uM by liquid scintillation counting | B | 4.2 | pIC50 | 62500 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
| ChEMBL | Inhibition of bee venom group 3 secretory phospholipase A2 by liquid scintillation counting | B | 5.12 | pIC50 | 7500 | nM | IC50 | J Nat Prod (2001) 64: 612-615 [PMID:11374954] |
| ChEMBL | Inhibition of bee venom secretory PLA2 | B | 5.12 | pIC50 | 7500 | nM | IC50 | J Nat Prod (1998) 61: 571-575 [PMID:9599251] |
| ChEMBL | Inhibitory activity against bee secretory Phospholipase A2 enzyme | B | 5.12 | pIC50 | 7500 | nM | IC50 | J Med Chem (1998) 41: 3232-3238 [PMID:9703468] |
| ChEMBL | Inhibition of bee venom group3 sPLA2 by liquid scintillation counting | B | 5.12 | pIC50 | 7500 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
| ChEMBL | Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem (2010) 18: 6006-6011 [PMID:20634081] |
| ChEMBL | Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1261-1264 [PMID:21256013] |
| sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054] | ||||||||
| ChEMBL | Inhibition of human synovial secretory PLA2 | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Nat Prod (1998) 61: 571-575 [PMID:9599251] |
| sPLA2-2A/Phospholipase A2 group IIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555] | ||||||||
| ChEMBL | Inhibition of human synovial group2 sPLA2 at 10 uM by liquid scintillation counting | B | 4.03 | pIC50 | 93200 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
| ChEMBL | Inhibitory activity against human synovial recombinant Phospholipase enzyme | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Med Chem (1998) 41: 3232-3238 [PMID:9703468] |
| ChEMBL | Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation counting | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Nat Prod (2001) 64: 612-615 [PMID:11374954] |
| ChEMBL | Inhibition of human synovial group2 sPLA2 by liquid scintillation counting | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
| GtoPdb | - | - | 5.41 | pIC50 | 3900 | nM | IC50 | J Nat Prod (1998) 61: 931-5 [PMID:9677277] |
| sPLA2-2A/Phospholipase A2 group IIA in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3686] [GtoPdb: 1417] [UniProtKB: P14423] | ||||||||
| ChEMBL | Inhibition of rat air pouch group2 sPLA2 at 10 uM by liquid scintillation counting | B | 4.42 | pIC50 | 38400 | nM | IC50 | J Nat Prod (1998) 61: 931-935 [PMID:9677277] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
