ponsegromab   Click here for help

GtoPdb Ligand ID: 13663

Synonyms: PF-06946860 | PF06946860
Compound class: Antibody
Comment: Ponsegromab (PF-06946860) is a humanized monoclonal antibody that binds and neutralises the action of the GDF-15 cytokine. It was designed to inhibit aberrant GDF-15/GDNF family receptor alpha like (GFRAL)-mediated dysregulation of appetite in human diseases, particularly in cancer patients.
Bioactivity Comments
Based on peptide sequence identities, ponsegromab carries identical VH and VL sequence strings with the antibody claimed as GDF15_001 in patent US11566066B2 [1]. GDF15_00 binds to human, murine and monkey GDF15 with binding affinities (Kd) of <10 pM.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
growth differentiation factor 15 Hs Inhibitor Inhibition - - - 2
⤷ [2]