cellular communication network factor 3   Click here for help

GtoPdb Ligand ID: 13454

Compound class: Endogenous peptide in human, mouse or rat
Comment: The cellular communication network factor 3 protein (CCN3) is a matricellular protein that is expressed during development. In endothelial cells it supports cell adhesion and survival through interactions with integrins (αvβ3, α5β1, α6β1) [2] and heparan sulfate proteoglycans. CCN3 induces cell migration through interactions with αvβ3 and α5β1 integrins.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
Reported as pro-osteogenic hormone in mice, that counteracts excessive bone resorption during lactation [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
integrin αVβ3 Ligand is endogenous in the given species Hs None Binding 8.0 pKd - 2
⤷ pKd 8.0 (Kd 1x10-8 M) [2]
Description: Measured by ELISA, as CCN3 binding to immobilized integrin
integrin α5β1 Ligand is endogenous in the given species Hs None Binding 7.3 pKd - 2
⤷ pKd 7.3 (Kd 5x10-8 M) [2]
Description: Measured by ELISA, as CCN3 binding to immobilized integrin