sofpironium   Click here for help

GtoPdb Ligand ID: 13426

Synonyms: BBI-4000 (sofpironium bromide) | Ecclock® | Sofdra®
Approved drug
sofpironium is an approved drug (Japan (2020))
Compound class: Synthetic organic
Comment: Sofpironium is an anticholinergic drug. It is a structural analogue of glycopyrrolate which was modified to be rapidly converted to an inactive metabolite in the circulation so as to restrict action to local sites of administration (i.e. it is a so-called retrometabolic or "soft" drug) and minimise potential systemic side-effects. In relation to its use to reduce sweating in axillary hyperhidrosis its effect is mediated by antagonism of M3 muscarinic acetylcholine receptors in eccrine glands.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 72.83
Molecular weight 390.49
XLogP 2.1
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOC(=O)C[N+]1(C)CC[C@H](C1)OC(=O)[C@](C2=CC=CC=C2)(C3CCCC3)O
Isomeric SMILES CCOC(=O)C[N+]1(CC[C@H](C1)OC(=O)[C@@](C2CCCC2)(C3=CC=CC=C3)O)C
InChI InChI=1S/C22H32NO5/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3/q+1/t19-,22+,23?/m1/s1
InChI Key SEVCTUCCZYBJER-BSJAROSPSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. Japan (2020)
IUPAC Name Click here for help
[(3R)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate
International Nonproprietary Names Click here for help
INN number INN
10398 sofpironium bromide
Synonyms Click here for help
BBI-4000 (sofpironium bromide) | Ecclock® | Sofdra®
Database Links Click here for help
ChEMBL Ligand CHEMBL3707224
GtoPdb PubChem SID 496703396
PubChem CID 86301317
Search Google for chemical match using the InChIKey SEVCTUCCZYBJER-BSJAROSPSA-N
Search Google for chemicals with the same backbone SEVCTUCCZYBJER
Search PubMed clinical trials sofpironium bromide
Search PubMed titles sofpironium bromide
Search PubMed titles/abstracts sofpironium bromide
UniChem Compound Search for chemical match using the InChIKey SEVCTUCCZYBJER-BSJAROSPSA-N
UniChem Connectivity Search for chemical match using the InChIKey SEVCTUCCZYBJER-BSJAROSPSA-N