tavapadon   Click here for help

GtoPdb Ligand ID: 13372

Synonyms: CVL-751 | PF-06649751
PDB Ligand
Compound class: Synthetic organic
Comment: Tavapadon (CVL-751) is an orally bioavailable, brain-penetrant, non-catechol dopamine D1/D5 receptor partial agonist [3-4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

tavapadon is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 71
Molecular weight 391.34
XLogP 1.61
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=C(C=CC(=C1)OC2=NC=CC=C2C(F)(F)F)C3=C(C)C(=O)NC(=O)N3C
Isomeric SMILES CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C
InChI InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
InChI Key AKQXQLUNFKDZBN-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrimidine-2,4-dione
International Nonproprietary Names Click here for help
INN number INN
10887 tavapadon
Synonyms Click here for help
CVL-751 | PF-06649751
Database Links Click here for help
Specialist databases
GPCRdb Ligand tavapadon
Other databases
BindingDB Ligand BDBM160918
CAS Registry No. 1643489-24-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL3697617
DrugBank Ligand DB14899
GtoPdb PubChem SID 496703342
PubChem CID 86764100
RCSB PDB Ligand 86W
Search Google for chemical match using the InChIKey AKQXQLUNFKDZBN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone AKQXQLUNFKDZBN
Search PubMed clinical trials tavapadon
Search PubMed titles tavapadon
Search PubMed titles/abstracts tavapadon
UniChem Compound Search for chemical match using the InChIKey AKQXQLUNFKDZBN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey AKQXQLUNFKDZBN-UHFFFAOYSA-N

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MedChemExpress
(Rac)-Tavapadon (links to external site)
Cat. No. HY-119486A