agouti-related protein   Click here for help

GtoPdb Ligand ID: 1335

Abbreviated name: AGRP
Synonyms: agouti-related peptide
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Fong TM, Mao C, MacNeil T, Kalyani R, Smith T, Weinberg D, Tota MR, Van der Ploeg LH. (1997)
ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors.
Biochem Biophys Res Commun, 237 (3): 629-31. [PMID:9299416]
2. Rosenfeld RD, Zeni L, Welcher AA, Narhi LO, Hale C, Marasco J, Delaney J, Gleason T, Philo JS, Katta V et al.. (1998)
Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein.
Biochemistry, 37 (46): 16041-52. [PMID:9819197]
3. Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I. (1999)
Characterization of Agouti-related protein binding to melanocortin receptors.
Mol Endocrinol, 13 (1): 148-55. [PMID:9892020]