cinpanemab 
GtoPdb Ligand ID: 13331
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Synonyms: antibody 12F4 | BIIB-054 | BIIB054
Compound class:
Antibody
Comment: Cinpanemab (BIIB054) is a monoclonal antibody that binds aggregated α-synuclein [3]. Specifically it binds to the N terminus of α-synuclein. It was designed to reduce the cell-to-cell spread of toxic α-synuclein aggregates in the brains of people with Parkinson's disease, as a disease-modifying therapeutic approach to slow the rate of neuronal damage and disease progression.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Bioactivity Comments |
| The BIIB054 Fab binds more tightly to α-synuclein aggregates than to monomeric α-synuclein, with the affinity for aggregated α-synuclein being around 800-fold higher [3]. |
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