famlasertib   Click here for help

GtoPdb Ligand ID: 13267

Synonyms: compound 12k [PMID: 31676236] | Prosetin | Prostetin [1]
Compound class: Synthetic organic
Comment: Compound 12k (prostetin/prosetin) is an oral, brain-penetrant MAP4 kinase inhibitor that exhibits a protective effect for motor neurons [1]. Functionally it reduces ER stress-mediated neurodegeneration as an outcome of the misfolded protein response in ALS neurons. It also has anti-inflammatory properties. The chemical structure of 12k is identical to that for the INN famlasertib (proposed list 132, Feb. 2025).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 51.1
Molecular weight 446.97
XLogP 1.5
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC(=CC(=C1)Cl)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)CN5CCN(CC5)CCO
Isomeric SMILES OCCN1CCN(CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC=CC(Cl)=C5)N=C3)CC1
InChI InChI=1S/C26H27ClN4O/c27-23-3-1-2-21(14-23)25-17-29-26-24(25)15-22(16-28-26)20-6-4-19(5-7-20)18-31-10-8-30(9-11-31)12-13-32/h1-7,14-17,32H,8-13,18H2,(H,28,29)
InChI Key VZJUKEQMHBEIKH-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[4-[[4-[3-(3-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]piperazin-1-yl]ethanol
International Nonproprietary Names Click here for help
INN number INN
13464 famlasertib
Synonyms Click here for help
compound 12k [PMID: 31676236] | Prosetin | Prostetin [1]
Database Links Click here for help
CAS Registry No. 2375591-69-6 (source: WHO INN record)
ChEMBL Ligand CHEMBL5413518
GtoPdb PubChem SID 491300049
PubChem CID 154677753
Search Google for chemical match using the InChIKey VZJUKEQMHBEIKH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VZJUKEQMHBEIKH
Search PubMed clinical trials famlasertib
Search PubMed titles famlasertib
Search PubMed titles/abstracts famlasertib
UniChem Compound Search for chemical match using the InChIKey VZJUKEQMHBEIKH-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VZJUKEQMHBEIKH-UHFFFAOYSA-N