Synonyms: XNW4107
Compound class:
Synthetic organic
Comment: Funobactam (XNW4107) is a novel serine β-lactamase inhibitor, belonging to the diazabicyclooctane (DBO) class [1]. It enhances the activity of carbapenem antibacterials against carbapenem-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae [1]. Funobactam is in clinical development in combination with imipenem + cilastatin for the treatment of complicated urinary tract infections (cUTIs) and hospital acquired/ventilator-associated bacterial pneumonia (HABP/VABP).
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
[(2S,5R)-2-[5-[(4S)-2-amino-4,5-dihydro-1H-imidazol-4-yl]-1,3,4-oxadiazol-2-yl]-7-oxospiro[1,6-diazabicyclo[3.2.1]octane-4,1'-cyclopropane]-6-yl] hydrogen sulfate |
International Nonproprietary Names | |
INN number | INN |
12132 | funobactam |
Synonyms |
XNW4107 |
Database Links | |
Specialist databases | |
Antibiotic DB | XNW4107, funobactam |
Other databases | |
CAS Registry No. | 2365454-12-0 (source: Scifinder) |
ChEMBL Ligand | CHEMBL5095101 |
GtoPdb PubChem SID | 491299896 |
PubChem CID | 158340749 |
Search Google for chemical match using the InChIKey | GRRBXZJDEZJMHA-FXQIFTODSA-N |
Search Google for chemicals with the same backbone | GRRBXZJDEZJMHA |
Search PubMed clinical trials | funobactam |
Search PubMed titles | funobactam |
Search PubMed titles/abstracts | funobactam |
UniChem Compound Search for chemical match using the InChIKey | GRRBXZJDEZJMHA-FXQIFTODSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GRRBXZJDEZJMHA-FXQIFTODSA-N |