cerebral dopamine neurotrophic factor   Click here for help

GtoPdb Ligand ID: 13048

Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class: Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
No information available.
Summary of Clinical Use Click here for help
The effect of centrally administered CDNF has been investigated in human volunteers with Parkinson's disease [3].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03775538 Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study Phase 1/Phase 2 Interventional Herantis Pharma Plc.
NCT03295786 Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease Phase 1/Phase 2 Interventional Herantis Pharma Plc.
NCT04228653 Long-Term Follow-up Safety After DDS Implantation With/Without CDNF Infusions Phase 1/Phase 2 Interventional Renishaw