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cerebral dopamine neurotrophic factor   Click here for help

GtoPdb Ligand ID: 13048

Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class: Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
Bioactivity Comments
A domain within the C-terminal domain of CDNF interacts with heat shock protein family A (Hsp70) member 5 (HSPA5; GRP78). CDNF/HSPA5 complexes interact with proteins (IRE1, PERK, and ATF6) that activate unfolded protein response (UPR) pathways.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
heat shock protein family A (Hsp70) member 5 Ligand is endogenous in the given species Hs None Binding - - -
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