Synonyms: (8S)-8-fluoroerythromycin A | P-0501A
flurithromycin is an approved drug
Compound class:
Synthetic organic
Comment: Flurithromycin is a 14-membered macrolide antibacterial compound, originally isolated from Streptomyces erythraeus using a mutational biosynthesis approach [4]. It is a fluorinated derivative of erythromycin with improved acid stability.
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References |
1. Fanos V, Mormile R, Benini D, Vecchini S, Cuzzolin L. (2000)
Flurithromycin-induced acute interstitial nephritis. Pediatr Infect Dis J, 19 (4): 366-7. [PMID:10783037] |
2. Hardy DJ, Hensey DM, Beyer JM, Vojtko C, McDonald EJ, Fernandes PB. (1988)
Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Antimicrob Agents Chemother, 32 (11): 1710-9. [PMID:3252753] |
3. Saverino D, Debbia EA, Pesce A, Lepore AM, Schito GC. (1992)
Antibacterial profile of flurithromycin, a new macrolide. J Antimicrob Chemother, 30 (3): 261-72. [PMID:1452490] |
4. Toscano L, Fioriello G, Spagnoli R, Cappelletti L, Zanuso G. (1983)
New fluorinated erythromycins obtained by mutasynthesis. J Antibiot (Tokyo), 36 (11): 1439-50. [PMID:6654754] |